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Objective To investigate the changes of bone mineral density (BMD) and its causing factors in menopausal female patients with type Ⅱ diabetes mellitus (DM2). Methods Dual energy X ray absorptimetry was used to measure the BMD of lumbar spines (L 2-4 ) and proximal femur in 82 female patients with type Ⅱ diabetes and 46 normal controls. According to BMD, DM2 patients were divided into two groups (DM A and DM B). Fasting plasma glucose (FPG), fasting plasma insulin (FINS), fasting plasma C peptide (FCP), glycated hemoglobin (HbAc1), urine albumin excretion rate (UAER), and urine ? 2 microglobin (? 2 MG) were measured and compared between the two groups. Results BMD of lumbar spines (L 2-4 ), femoral neck and Ward's triangle in diabetic patients were significantly lower than that of the controls ( P
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Objective:To study the effects of valproate sodium and topiramate on spontaneous motor activity behavior and isolation-induced aggression in mice,and thus to provide evidence for drug treatment.Methods:Male Kunming mice were isolated for 40～45days as an animal model of isolation-induced aggression.The isolated and group-housed mice were administrated with different doses of valproate sodium (0mg/kg、50mg/kg、100mg/kg、200mg/kg) and topiramate(0mg/kg、25mg/kg、50mg/kg、100mg/kg).The aggressiveness of isolated mice was measured 30min after the administration of valproate sodium or 120min after the administration of topiramate.Results:Valproate sodium and topiramate could dose-dependently prolong the latencies to attacking.They could also decrease spontaneous motor activity.Conclusion:Both valproate sodium and topiramate are inhibitors of aggression behavior in isolated mice.Topiramate and valproate sodium have synergism.
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Objective:To study the differences and similarities in the personality traits between violent schizophrenic patients and violent criminals.Methods:A controlled study was conducted between 49 violent criminals and 35 schizophrenic patients with violent behaviors.They were assessed using Minnesota Multiphasic Personality Inventory(MMPI),Personality Diagnostic Questionnaire-4th Version(PDQ4+).Results:(1)Schizophrenic patients had higher F,D,Hs,Hy,Pa scores of MMPI than violent criminals.(2)Compared with violent criminals,schizophrenic patients had higher scores in paranoid,schizoid,schizotypal,hysteric,dependent,passive aggressive and depressive personality disorders and had lower scores in antisocial personality disorders of PDQ4+.Conclusion:There are significant differences between two groups in the personality traits,while each group has some similar personality deviation.